In practice the single-particle space has to be severely truncated. This truncation is typically based upon the single-particle energies, which is the effective energy from a mean-field potential.
Sometimes we freeze the core and only consider a valence space. For example, one may assume a frozen 4He core, with two protons and two neutrons in the 0s1/2 shell, and then only allow active particles in the 0p1/2 and 0p3/2 orbits.
Another example is a frozen 16O core, with eight protons and eight neutrons filling the 0s1/2, 0p1/2 and 0p3/2 orbits, with valence particles in the 0d5/2,1s1/2 and 0d3/2 orbits.
Sometimes we refer to nuclei by the valence space where their last nucleons go. So, for example, we call 12C a p-shell nucleus, while 26Al is an sd-shell nucleus and 56Fe is a pf-shell nucleus.